Solution thermodynamics of methocarbamol in some ethanol + water mixtures

Química Nova

Universidad Nacional de Colombia, Bogotá, Colombia¹  Rodríguez, Gerson A.¹  Delgado, Daniel R.¹  Mercado, Katia C.¹  Martínez, Fleming¹  Romdhani, Asma¹  University of Monastir, Tunisia¹ 

关键词: cosolvency;    methocarbamol;    solubility.;   

DOI  :  10.1590/S0100-40422012001000015

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Apparent thermodynamic functions, Gibbs energy, enthalpy and entropy of solution and mixing, for methocarbamol in ethanol + water mixtures, were evaluated from solubility data determined at temperatures from 293.15 K to 313.15 K and from calorimetric values of drug fusion. The drug solubility was greatest in the mixtures with 0.70 or 0.80 mass fraction of ethanol and lowest in neat water across all temperatures studied. Non-linear enthalpy-entropy compensation was found for the dissolution processes. Accordingly, solution enthalpy drives the respective processes in almost all the solvent systems analyzed.

【 授权许可】

Unknown