Chemical constituents of the leaves from Rollinia leptopetala R. E. Fries

Química Nova

Castello-Branco, Marianna V. S.¹  Pita, João Carlos L. R.¹  Silva, Marcelo Sobral da¹  Santos, Bárbara Viviana de O.¹  Costa, Vicente Carlos de O.¹  Lima, Carolina Uchôa G. B. de¹  Universidade Federal da Paraíba, João Pessoa, Brasil¹  Sette, Ivana Maria Fechine¹  Queiroga, Cinthia S.¹  Diniz, Margareth F. F. Melo¹  Tavares, Josean F.¹  Universidade Estadual da Paraíba, Campina Grande, Brasil¹ 

关键词: Rollinia leptopetala;    α;    -terpinyl caffeate;    alkaloids.;   

DOI  :  10.1590/S0100-40422012000100025

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The phytochemical investigation of Rollinia leptopetala led to the isolation of a new compound named α-terpinyl caffeate, and five known compounds, being three sesquiterpenes, spathulenol, β-caryophyllene and 4β,10α-aromadendrane-diol, and two alkaloids, (-)-3-hydroxynornuciferine and (+)-norisocorydine. These alkaloids are being described for the first time in this genus. The structures of the compounds were determined by analysis of IR, MS and NMR data, as well as by comparison with literature data. The crude extract of R. leptopetala leaves demonstrated a weak cytotoxicity on sarcoma 180 cells with an IC50 of 512.3 µg/mL. However, the in vivo results showed that the extract exhibited a significant dose-dependent tumor growth reduction.

【 授权许可】

Unknown