A polivalent flow system for the spectrophotometric determination of pharmaceuticals

Química Nova

Universidade de São Paulo, São Paulo, Brasil¹  Schmidt Jr, Erlando¹  Melchert, Wanessa R¹  Rocha, Fábio R. P¹  Universidade de São Paulo, Piracicaba, Brasil¹ 

关键词: flow analysis;    pharmaceuticals;    sequential determination.;   

DOI  :  10.1590/S0100-40422011000700019

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A flow system based on the sandwich technique is proposed for the sequential determination of ascorbic acid, dipyrone, acetylcysteine, captopril and paracetamol. The procedure is based on the reduction of Cu(II) by the analytes followed by the spectrophotometric measurement of the complex of Cu(I) with 2,2'-biquinoline 4,4'-dicarboxylic acid. Linear responses were achieved in the µmol L-1 range, with coefficients of variation better than 1.7%. Sampling rate was estimated as 60 determinations per hour, consuming 230 µg of BQA and generating 2.5 mL of waste per determination. Results for commercial samples agreed with those obtained by procedures recommended by the American and European pharmacopeias at the 95% confidence level.

【 授权许可】

Unknown