Development and validation of a method for the analysis of tetracyclines in chicken-muscle by liquid chromatography-electrospray-mass spectrometry in tandem (LC-ESI-MS/MS)

Química Nova

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil¹  Gomes, Luiz Nelson F¹  Aquino Neto, Francisco Radler¹  Uekane, Thais Matsue¹ 

关键词: tetracyclines;    chicken-muscle;    validation.;   

DOI  :  10.1590/S0100-40422011000100009

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A LC-ESI-MS/MS method was developed and validated according to the European Union decision 2002/657/EC, for the determination of tetracyclines (TCs) in chicken-muscle since Europe is one of the main markets for Brazilian products. Linearity of r > 0.9979, limits of quantification in the range of 7.0-35.0 ng/g, average recoveries of 89.38 - 106.27%, within-day and between-day precision were adequate for all TCs. The decision limit and the detection capability were 93.00-106.46 ng/g and 95.84-114.38 ng/g, respectively. This method is suitable for application in surveillance programmes of residues of TCs in chicken-muscle samples.

【 授权许可】

Unknown