In vitro study of antioxidant and scavenger properties of phenolic compounds from Lychnophora species

Química Nova

Gobbo-Neto, Leonardo¹  Kabeya, Luciana M.¹  Lucisano-Valim, Yara M.¹  Kanashiro, Alexandre¹  Takeara, Renata¹  Universidade de São Paulo, Ribeirão Preto, Brasil¹  Grael, Cristiane F. F.¹  Lopes, Norberto P.¹  Polizello, Ana Cristina M.¹  Jordão, Christiane O.¹  Lopes, João Luis C.¹ 

关键词: antioxidant activity;    Lychnophora;    flavonoids.;   

DOI  :  10.1590/S0100-40422010000400019

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This paper describes the antioxidant effects of thirteen phenolic compounds isolated from plants of the genus Lychnophora. Two assays were performed to evaluate these effects: a cellular test that measured the luminol-enhanced chemiluminescence produced by neutrophils stimulated with opsonized zymosan and a cell-free test involving horseradish peroxidase-H2O2-luminol. In both assays, the antioxidant activity of the phenolic compounds was dependent on their concentration and chemical structure. Our results suggest that the ability of phenolic compounds from Lychnophora species to scavenge and inhibit the generation of ROS may be a mechanism underlying the anti-inflammatory activity of extracts from Lychnophora spp.

【 授权许可】

Unknown