Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with HPLC

Química Nova

Malesuik, Marcelo Donadel¹  Steppe, Martin¹  Schapoval, Elfrides Eva Scherman¹  Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil¹  Paim, Clésio Soldatelli¹ 

关键词: Nitazoxanide;    UV-spectrophotometry;    method validation.;   

DOI  :  10.1590/S0100-40422010000300045

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A rapid, economical, reproducible, and simple direct spectrophotometric method was developed and validated for the assay of nitazoxanide in pharmaceutical formulations. Nitazoxanide concentration was estimated in water at 345 nm and pH 4.5. The method was suitable and validated for specificity, linearity, precision, and accuracy. There was no interference of the excipients in the determination of the active pharmaceutical ingredient. The proposed method was successfully applied in the determination of nitazoxanide in coated tablets and in powders for oral suspension. This method was compared to a previously developed and validated method for liquid chromatography to the same drug. There was no significative difference between these methods for nitazoxanide quantitation.

【 授权许可】

Unknown