Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets

Química Nova

Universidade Federal do Piauí, Teresina, Brasil¹  Silva, Keyla Emanuelle Ramos da¹  Soares Sobrinho, José Lamartine¹  Alves, Lariza Darlene Santos¹  Soares, Mônica Felts de La Roca¹  Universidade Federal de Pernambuco, Recife, Brasil¹  Grangeiro Júnior, Severino¹  Rolim Neto, Pedro José¹ 

关键词: ornidazole;    quality control;    dissolution test.;   

DOI  :  10.1590/S0100-40422010000200042

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This work aimed the development and validation of a new dissolution test for ornidazole coated tablets. The dissolution conditions were determined after testing Sink conditions, dissolution medium, apparatus, stirring speed, 24 h stability and medium filtration influence. The best conditions were paddle at a stirring speed of 75 rpm and 900 mL of 0.1 M HCl. A new HPLC quantification method was developed and validated. The dissolution test and quantification method showed to be adequate for their purposes and could be applied for quality control of ornidazole coated tablets, since there is no official monograph.

【 授权许可】

Unknown