Química Nova | |
Optimization and intralaboratorial validation of method for analysis of chloramphenicol residues in goat milk by GC/ECD | |
Universidade Federal da Bahia, Salvador, Brasil1  Silva, Luciana T.1  Silva, Jaff R. da1  Druzian, Janice I.1  | |
关键词: chloramphenicol residues; goat milk; GC/ECD.; | |
DOI : 10.1590/S0100-40422010000100017 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
The presence of chloramphenicol residues in goat milk can cause toxic effects in the population. The present work consists of the optimization and validation of analytical methodology for determination of chloramphenicol residues in goat milk by GC/ECD. The extraction was made with ethyl acetate and the clean-up with SPE-C18. The identification was made by comparison of retention time and GC/MS, and the quantification by external standard. The method was selective, linearity (0.998), precise (5.8-13.4%), exact (69.87-73.71%) and robust. The LOD and LOQ of method were 0.030 and 0.10 μg/kg, respectively. The method was efficiently for analysis of chloramphenicol in goat milk.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912050594784ZK.pdf | 295KB | download |