Chemotherapy of Chagas' disease: state of the art and perspectives for the development of new drugs

Química Nova

Andricopulo, Adriano D.¹  Universidade de São Paulo, São Carlos, Brasil¹  Silva, Jean Jerley N.¹  Thiemann, Otavio H.¹  Universidade Estadual de Campinas, Campinas, Brasil¹  Dessoy, Marco A.¹  Oliva, Glaucius¹  Dias, Luiz C.¹ 

关键词: Chagas' disease;    enzymes;    inhibitors.;   

DOI  :  10.1590/S0100-40422009000900038

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Neglected diseases are a major global cause of illness, long-term disability and death. Chagas' disease is a parasitic infection widely distributed throughout Latin America, with devastating consequences in terms of human morbidity and mortality. The existing drug therapy suffers from a combination of drawbacks including poor efficacy, resistance and serious side effects. In 2009, we celebrate the 100th anniversary of the discovery of Chagas' disease, facing the challenges of developing new, safe and effective drugs for the treatment of this disease. This brief review attempts to highlight the state of the art, limitations and perspectives of Chagas' disease drug development.

【 授权许可】

Unknown