QSAR 3D studies of a series of human butyrylcholinesterase inhibitors

Química Nova

Universidade Federal da Bahia, Salvador, Brasil¹  Paz, Odailson S.¹  Freitas, Humberto F.¹  Castilho, Marcelo S.¹ 

关键词: butyrylcholinesterase;    Alzheimer;    QSAR 3D.;   

DOI  :  10.1590/S0100-40422009000800024

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Alzheimer's disease (AD) is considered the main cause of cognitive decline in adults. The available therapies for AD treatment seek to maintain the activity of cholinergic system through the inhibition of the enzyme acetylcholinesterase. However, butyrylcholinesterase (BuChE) can be considered an alternative target for AD treatment. Aiming at developing new BuChE inhibitors, robust QSAR 3D models with high predictive power were developed. The best model presents a good fit (r2=0.82, q2=0.76, with two PCs) and high predictive power (r2predict=0.88). Analysis of regression vector shows that steric properties have considerable importance to the inhibition of the BuChE.

【 授权许可】

Unknown