Determination of ambroxol in syrups using diffuse reflectance spectroscopy

Química Nova

Pezza, Leonardo¹  Pezza, Helena R.¹  Rodrigues, Mayra A.¹  Universidade Estadual Paulista, Araraquara, Brasil¹  Santos, Joel M.¹  Rufino, José L.¹ 

关键词: ambroxol;    diffuse reflectance spectroscopy;    p-dimethylaminocinnamaldehyde.;   

DOI  :  10.1590/S0100-40422009000600029

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This paper reports an analytical method for the determination of ambroxol in micellar medium by spot test-diffuse reflectance spectroscopy. The reflectance measurements were performed analyzing the colored compound (λ= 520 nm) produced from the reaction between ambroxol and p-dimethylaminocinnamaldehyde on the surface filter paper. The linear range was from 1.21 × 10"3 to 9.65 × 10"3 mol L-1 (500 - 4000 μg mL-1). The limit of detection and quantification were 3.50 x 10-4 mol L-1 (145 μg mL-1) and 1.16 x 10-3 mol L-1 (481 μg mL-1), respectively. Five commercial samples were analysed and the results obtained by the proposed method were in good agreement with those obtained by the literature method at 95% confidence level.

【 授权许可】

Unknown