Organocatalysis reactions with chiral amines: mechanistic aspects and use on organic synthesis

Química Nova

Coelho, Fernando¹  Universidade Estadual de Campinas, Campinas, Brasil¹  Amarante, Giovanni W.¹ 

关键词: organocatalysis;    amines;    asymmetric synthesis.;   

DOI  :  10.1590/S0100-40422009000200034

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The philosophy of organocatalysis is based on the utilization of organic compounds to catalyze organic transformations without the intervention of metals. This area has attracted much attention of the synthetic chemistry community on the last years, which can be confirmed by the explosion of published papers dealing with this subject. Phosphorus compounds, urea and thiourea derivatives, alkaloids, guanidine derivatives, for example, have already been used as organocatalysts. In this review we have focused on the use of chiral amines as organocatalyst. We have also chosen some outstanding examples to demonstrate the potentiality of this strategy in the synthesis of natural products and biologically active compounds.

【 授权许可】

Unknown