Synthesis of aminoalcohols from D-mannitol

Química Nova

Oliveira, Pedro S. M. de¹  Universidade Federal Fluminense, Niterói, Brasil¹  Fundação Oswaldo Cruz, Rio de Janeiro, Brasil¹  Souza, Marcus Vinicius N. de¹  Carvalho, Erika Martins de¹  Ferreira, Vitor F.¹ 

关键词: aminoalcohols;    mannitol;    tuberculosis.;   

DOI  :  10.1590/S0100-40422008000400013

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Aminoalcohols have found important applications in synthetic and medicinal chemistry, being used as chiral building blocks for the synthesis of many biologically active compounds. This class of compounds has been also used as chiral auxiliaries and ligands in asymmetric synthesis. Due to the importance of aminoalcohols in the treatment of several diseases, such as tuberculosis, the aim of this article is the synthesis and preliminary evaluation against tuberculosis of six aminoalcohols in 5 or 6 steps using D-mannitol as starting material, which is a useful carbohydrate employed in many syntheses.

【 授权许可】

Unknown