Chemical constituents from Bakeridesia pickelii Monteiro (Malvaceae) and the relaxant activity of kaempferol-3-O-beta-D-(6"-E-p -coumaroyl) glucopyranoside on guinea-pig ileum

Química Nova

Agra, Maria de Fátima¹  Cavalcanti, Aline Coutinho¹  Lima, Julianeli Tolentino de¹  Cavalcante, José Marcílio Sobral¹  Souza, Maria de Fátima Vanderlei de¹  Costa, Danielly Albuquerque da¹  Silva, Davi Antas e¹  Silva, Bagnólia Araújo da¹  Medeiros, Marcos Antônio Alves de¹ 

关键词: malvaceae;    Bakeridesia pickelii;    relaxant activity.;   

DOI  :  10.1590/S0100-40422007000400026

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The phytochemical investigation of Bakeridesia pickelii Monteiro led to the isolation of seven compounds: b-sitosterol, a mixture of sitosteryl-3-O-b-D-glucopyranoside and stigmasteryl-3-O-b-D-glucopyranoside, vanillic acid, p-coumaric acid, quercetin 3-O-b-D-glucopyranoside (isoquercitrin) and kaempferol-3-O-b-D-(6"-E-p -coumaroyl) glucopyranoside (tiliroside), which was isolated as the major component. Their structures were elucidated on the basis of spectroscopic data such as IR, 1H and 13C NMR, including two-dimensional techniques. Tiliroside relaxed the guinea-pig ileum pre-contracted with KCl 40 mM (EC50 = 9.5 ± 1.0 x 10-5 M), acetylcholine 10-6 M (EC50 = 2.3 ± 0.9 x 10-5 M) or histamine 10-6 M (EC50 = 4.1 ± 1.0 x 10-5 M) in a concentration-dependent manner.

【 授权许可】

Unknown