Control of the biosynthesis of bacterial polyhydroxyalkanoates through the flux of substrates

Química Nova

Instituto de Pesquisas Tecnológicas do Estado de São Paulo S.A., São Paulo, Brasil¹  Pradella, José Geraldo da Cruz¹  Pereira, Fabrício Saab¹  Rocha, Rafael Costa Santos¹  Taciro, Marilda Keico¹  Rodrigues, Maria Filomena de Andrade¹ 

关键词: polyhydroxyalkanoates;    P3HB-co-3HV;    P3HB-b-3HPE.;   

DOI  :  10.1590/S0100-40422007000100012

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Manipulation of the flux of substrates was utilized to control the amount of 3-hydroxyvalerate and 3-hydroxy-4-pentenoate produced by Burkohlderia sp. The 3HV production rate was directly proportional to the propionic acid uptake rate with the last one completely directed to 3HV biosynthesis. The 3HPE production rate was inversely proportional to the sucrose uptake rate probably due to operation of the glyoxylate cycle.

【 授权许可】

Unknown