Methyl coenzyme M reductase and the factor 430

Química Nova

Caiut, José Maurício Almeida¹  Universidade Federal do Paraná, Curitiba, Brasil¹  Friedermann, Geraldo Roberto¹  Nakagaki, Shirley¹ 

关键词: nickel complexes;    coenzyme M reductase;    F430.;   

DOI  :  10.1590/S0100-40422006000500022

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This review presents studies on methyl coenzyme M reductase, the biological system Factor 430 (F430) and the use of nickel(II) complexes as structural and functional models. The ability of F430 and nickel(II) macrocycle complexes to mediate the reductive dehalogenation of cyclohexyl halogens and the CH3-S bond cleavage of methyl CoM (by sodium borohydride and some intermediate species) proposed for the catalytic cycle of the biological system F430 was reviewed. The importance of the structure of the nickel complexes and the condition of the catalytic reduction reaction are also discussed.

【 授权许可】

Unknown