Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules

Química Nova

Taborianski, Andréia M.¹  Singh, Anil Kumar¹  Kedor-Hackmann, Erika R. M.¹  Santoro, Maria Inês R. M.¹  Universidade de São Paulo¹ 

关键词: liquid chromatography;    antiviral drugs;    stability studies.;   

DOI  :  10.1590/S0100-40422006000200012

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Zidovudine (AZT) and stavudine (D4T) are nucleoside reverse transcriptase inhibitors extensively used in human immunodeficiency virus (HIV) infected patients. In order to evaluate the quality of these drugs, two stability indicating HPLC methods were developed. The validated methods were applied in quantitative determination of AZT, D4T and their induced degradation products in capsule preparations. The stability studies were conducted at controlled temperature and relative humidity conditions based on the International Conference on Harmonization stability studies protocol for Zone IV areas. Easy sample preparation and low-cost make these methods especially useful for quality control and stability studies of AZT and D4T in drug products.

【 授权许可】

Unknown