Activation of mice peritoneal macrophages by palladium(II) organometallic mononuclear compounds

Química Nova

Carlos, Iracilda Zeppone¹  Santana, Anderson Martinez¹  Godoy Netto, Adelino Vieira de¹  de Almeida, Eduardo Tonon¹  Universidade Estadual Paulista, Araraquara¹  Mauro, Antonio Eduardo¹ 

关键词: palladium(II) complexes;    macrophages;    hydrogen peroxide.;   

DOI  :  10.1590/S0100-40422005000300008

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The immune responses are mediated by a variety of cells that, when activated, produce a number of molecules. Macrophages are the first cells to take part in the immune response releasing many compounds in the extracellular environment such as H2O2. Taking into account this aspect we evaluated the activation of an immunological system, in vitro, by determining the H2O2 released in cultures of peritoneal macrophage cells from Swiss mice in the presence of organopalladated compounds of the type [Pd(dmba)(X)(dppp)], dmba = N,N-dimethylbenzylamine, dppp = 1,3-bis(diphenylphosphine)propane, X = Cl, N3, NCO, NCS. An excellent activation of macrophages by the [Pd(dmba)(X)(dppp)] compounds was observed and the influence of the X ligand on the immune response could be verified.

【 授权许可】

Unknown