Schizophrenia: forty years of the dopaminergic hypothesis from the medicinal chemistry point of view

Química Nova

Lima, Vera Lucia Eifler¹  Universidade Federal do Rio de Janeiro, Rio de Janeiro¹  Universidade Federal do Rio Grande do Sul, Porto Alegre¹  Rates, Stela Maris Kuze¹  Barreiro, Eliezer J.¹  Fraga, Carlos Alberto Manssour¹  Dalla Costa, Teresa¹  Menegatti, Ricardo¹ 

关键词: schizophrenia;    antipsychotic drugs;    dopamine receptor ligands.;   

DOI  :  10.1590/S0100-40422004000300015

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and continues as a challenge to neuroscience. In this work, we describe an account about the historical evolution of the dopaminergic hypothesis of schizophrenia discussing, from the medicinal chemistry point of view all different classes of antipsychotic drugs, emphasizing the rational design, structure activity relationships (SAR) and physico-chemical properties related with its molecular mechanism of action.

【 授权许可】

Unknown