Catalytic asymmetric aldol reactions

Química Nova

Corrêa Jr., Ivan R.¹  Pilli, Ronaldo A.¹  Universidade Estadual de Campinas, Campinas¹ 

关键词: aldol reaction;    asymmetric catalysis;    enantioselective synthesis.;   

DOI  :  10.1590/S0100-40422003000400016

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This review describes the use of catalytic asymmetric aldol reactions of silyl enol ethers and silyl (thio)ketene acetals with aldehydes (the Mukaiyama aldol reaction) in order to illustrate its synthetic utility. A variety of Lewis acid and basic reagents were employed for catalytic aldol reactions with high diastereo- and enantioselectivities. The origins of the selectivity of these reactions are discussed and some representative examples of their application in the synthesis of natural products are presented. New developments in chiral heterobimettalic lanthanoid catalysis and enantioselective aldol reactions in aqueous media are also included.

【 授权许可】

Unknown