Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes

Journal of the Brazilian Chemical Society

Modolo, Luzia V.¹  Barbosa, Gisele Maria¹  Fátima, Ângelo de¹  Universidade Federal de Minas Gerais, Belo Horizonte, Brazil¹  Horta, Lívia P.¹  Mota, Yane C. C.¹  Empresa Brasileira de Pesquisa Agropecuária, Sete Lagoas, Brazil¹  Marriel, Ivanildo E.¹  Braga, Taniris C.¹ 

关键词:  urea;    urease inhibitor;    natural product;    phenolic aldehyde;    fertilizer additive;   

DOI  :  10.21577/0103-5053.20160208

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The plant phenolic natural products (PNPs) protocatechuic aldehyde, syringaldehyde and vanillin were used as platforms for obtaining four urease inhibitors. Urea (urease substrate) or thiourea (urease inhibitor) core was added to the structure of newly synthesized compounds to provide inhibitors up to 230-fold more active than the PNPs they originated from. The PNP derivatives are mixed inhibitors with higher affinity to urease active site. Two compounds were as efficient as N-(butyl)thiophosphoric triamide (NBPT) toward soil. Overall, PNPs derivatives are promising urease inhibitors for use as additive in urea-based fertilizers formulations.

【 授权许可】

Unknown