Genome Mining of Endophytic Streptomyces wadayamensis Reveals High Antibiotic Production Capability

Journal of the Brazilian Chemical Society

University of Cambridge, Cambridge, United Kingdom¹  Araújo, Welington L.¹  Vivian, Adriana F.¹  Schmidt, Eduardo M.¹  Samborskyy, Markiyan¹  Oliveira, Luciana G. de¹  Universidade de São Paulo, São Paulo, Brazil¹  Paulo, Bruno S.¹  Universidade Estadual de Campinas, Campinas, Brazil¹  Eberlin, Marcos N.¹  Sigrist, Renata¹  Angolini, Célio F. F.¹  Gonçalves, Ana B.¹  Cruz, Pedro L. R.¹ 

关键词:  genome sequencing;    genome mining;    molecular networking;    Streptomyces;    antibiotic activity;   

DOI  :  10.5935/0103-5053.20160180

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The actinobacteria Streptomyces wadayamensis A23, an endophitic strain, was recently sequenced and previous work showed qualitatively that the strain inhibits the growth of some pathogens. Herein we report the genome analysis of S. wadayamensis which reveals several antibiotic biosynthetic pathways. Using mass spectrometry, we were able to identify desferoxamines, several antimycins and candicidin, as predicted. Additionally, it was possible to confirm that the biosynthetic machinery of the strain when compared to identified known metabolites is far underestimated. As suggested by biochemical qualitative tests, genome encoded information reveals that the strain A23 has high capability to produce antibiotics.

【 授权许可】

Unknown