Antiprotozoal Activity of the Cyclopalladated Complexes Against Leishmania amazonensis and Trypanosoma cruzi

Journal of the Brazilian Chemical Society

Mauro, Antonio E.¹  Cistia, Mayara L. Del¹  Ribeiro, Aline R.¹  Chin, Chung M.¹  Passalacqua, Thaís G.¹  Rosa, João A. da¹  Almeida, Leticia de¹  Scontri, Mateus¹  Universidade Estadual de Campinas, Campinas, Brazil¹  Velásquez, Angela M. A.¹  Graminha, Marcia A. S.¹  Universidade Estadual Paulista, Araraquara, Brazil¹  Souza, Rodrigo A. de¹ 

关键词:  cyclopalladated;    leishmaniasis;    Chagas disease;    Leishmania amazonensis;    Trypanosoma cruzi;    trypanosomiasis;   

DOI  :  10.5935/0103-5053.20150360

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The present study describes the antiprotozoal activities of four cyclopalladated compounds, [Pd(dmba)(μ-Cl)]2, [Pd(dmba)(NCO)(isn)], [Pd(dmba)(N3)(isn)] and [Pd(dmba)(μ-NCO)]2, (dmba: N,N'-dimethylbenzylamine and isn: isonicotinamide), against the diseases leishmaniasis (Leishmania amazonensis and Leishmania infantum), Chagas disease (Trypanosoma cruzi) and human African trypanosomiasis (Trypanosoma brucei). [Pd(dmba)(μ-NCO)]2 exhibited good leishmanicidal and trypanocidal activities against L. amazonensis and T. cruzi intracellular amastigote forms, with a 50% inhibitory concentration (IC50) value of less than 9 µM and selectivity indexes of 14.47 and 28.42, respectively. Stability essays were conducted in phosphate buffer saline (PBS) pH 7.0 and showed that [Pd(dmba)(μ-NCO)]2 is the most stable molecule. These findings indicate that this compound presented higher selectivity for these parasites than the other tested compounds. The data presented here suggest that this compound should be considered in the development of new and more potent drugs for the treatment of leishmaniasis and Chagas disease.

【 授权许可】

Unknown