HR-MAS NMR for Rapid Identification of Illicit Substances in Tablets and Blotter Papers Seized by Police Department

Journal of the Brazilian Chemical Society

Universidade Federal de Mato Grosso do Sul, Campo Grande, Brazil¹  Superintendência da Polícia Técnico-Científica do Estado de Goiás, Goiânia, Brazil¹  Lião, Luciano M.¹  Alcantara, Glaucia B.¹  Instituto Federal do Tocantins, Araguatins, Brazil¹  Universidade Federal de Goiás, Goiânia, Brazil¹  Vieira, Tarcísio S.¹  Souza,, Luciano F.¹ 

关键词:  designer drugs;    psychoactive substances;    1H HR-MAS NMR;    fast identification;   

DOI  :  10.5935/0103-5053.20160106

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Illicit substances found in blotter papers and tablets seized by police are traditionally identified and characterized from extracts of these materials. However, the procedures involved in extraction stages can result in artifacts and even contamination of the samples to be analyzed. On the other hand, high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) is a technique that requires no pretreatment steps, enabling direct analysis of the material, including the analysis of new illegal synthetic psychoactive substances. This study presents and discusses applications of the HR-MAS NMR in the analysis of tablets and blotter papers seized. Additional analysis in solution of the extracts of these materials was performed to compare the obtained spectral resolution signals. The results demonstrated that the HR-MAS NMR allowed the rapid identification of 3,4-methylenedioxy-N-methylcathinone (methylone), 4-methylmethcathinone (mephedrone), 2,5-dimethoxy-4-bromoamphetamine (DOB) and 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25B-NBOMe) in samples of tablets and blotter papers seized in Goiás State, Brazil.

【 授权许可】

Unknown