Synthesis and Antifungal Activity Against Candida Strains of Mesoionic System Derived From 1,3-Thyazolium-5-thiolate

Journal of the Brazilian Chemical Society

Lira, Bruno F.¹  Lima, Edeltrudes O.¹  Athayde-Filho, Petrônio F. de¹  Peixoto, Isabelle N.¹  Souza, Helivaldo D. S.¹  Barbosa-Filho, José M.¹  Silva, Daniele F.¹  Universidade Federal da Paraíba, João Pessoa, Brazil¹ 

关键词:  isopropyl mesoionic derivatives;    antifungal activity;    in silico;   

DOI  :  10.5935/0103-5053.20160063

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A series of ten new compounds have been synthetized in satisfactory yields (85-95%) through the treatment of isopropyl mesoionic 1,3-thiazolium-5-thiolate with 2-chloro-N-arylacetamides and characterized by elemental analysis, infrared (IR), 1H and 13C nuclear magnetic resonance (NMR) spectroscopies. The newly synthesized compounds were evaluated as new drug candidates in in silico study and for their antifungal activity against several strains of Candida albicans. In silico study indicates that no compound has potential to be a new drug while four compounds showed medium to strong activity with minimum inhibitory concentration (MIC) range of 256-1024 µg mL-1.

【 授权许可】

Unknown