Ibuprofen, Carbamazepine and β-Estradiol Determination Using Thin-Film Microextraction and Gas Chromatography-Mass Spectrometry

Journal of the Brazilian Chemical Society

Pontificia Universidad Católica de Chile, Santiago, Chile¹  Universidad Tecnológica Metropolitana, Santiago, Chile¹  Ascar, Loreto¹  Giordano, Ady¹  Vásquez, José¹  Retamal, Mauricio¹  Universidad de Chile, Santiago, Chile¹ 

关键词:  thin-film extraction;    β-estradiol;    carbamazepine;    ibuprofen;   

DOI  :  10.5935/0103-5053.20160055

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The use of thin-film microextraction for the extraction of selected pharmaceutical compounds followed by gas chromatography-mass spectrometry detection was evaluated. A segment of polysiloxanes polymer sheet was used as low cost, single use, disposable extraction phase, while Milli-Q water spiked at 20 µg L−1 with the analytes was used for the optimization assays. The controlling parameters for the extraction were optimized via experimental design and it was found that an extraction time of 3 h using a sample volume of 1000 mL at pH 4 with the addition of 20% methanol and 20% sodium chloride provided the greatest extraction efficiency. Recoveries between 67.1 and 85.0% were achieved, with a repeteability lower than 20% (expressed as coefficient of variation) and limit of detection ranged from 0.41 and 0.92 µg L−1. The proposed method show similar analytical performance when compared to the determination of the analytes using stir bar sorptive extraction.

【 授权许可】

Unknown