Rodriguesic acids, modified diketopiperazines from the gastropod mollusc Pleurobranchus areolatus

Journal of the Brazilian Chemical Society

Andersen, Raymond J.¹  Ferreira, Antonio G.¹  Santos, Mario F. C.¹  Universidade Federal de São Carlos, São Carlos, Brazil¹  Ludwig-Maximilians-Universität München, Germany¹  Universidade de São Paulo, São Carlos, Brazil¹  Pereira, Fabio R.¹  Williams, David E.¹  University of British Columbia, Canada¹  Berlinck, Roberto G. S.¹  Padula, Vinicius¹ 

关键词: nudipleura;    Pleurobranchus;    diketopiperazine;    hydroxamate;    mollusc.;   

DOI  :  10.5935/0103-5053.20140037

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

In the present investigation, two specimens of the nudipleuran mollusc Pleurobranchus areolatus have shown to accumulate oxidized rodriguesin A derivatives. Rodriguesic acid presents a carboxylic acid replacing the terminal methyl group of the alkyl chain of rodriguesin A. A hydroxamate group was also present on the diketopiperazine moiety of a rodriguesic acid derivative. The structures of both rodriguesic acid and of rodriguesic acid hydroxamate have been established by analysis of spectroscopic data, including their absolute configuration. Two methyl esters of the rodriguesic acids have been isolated as major compounds, but were considered to be isolation artifacts.

【 授权许可】

Unknown