Simultaneous determination of paracetamol and ibuprofen in pharmaceutical samples by differential pulse voltammetry using a boron-doped diamond electrode

Journal of the Brazilian Chemical Society

Lima, Amanda B.¹  Universidade Federal dos Vales do Jequitinhonha e Mucuri¹  Guimarães, Carlos F. R. C.¹  Verly, Rodrigo M.¹  Silva, Leonardo M. da¹  Santos, Wallans T. P. dos¹  Carvalho Júnior, Álvaro D.¹  Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil¹  Torres, Lívia M. F. C.¹ 

关键词: simultaneous analysis;    differential pulse voltammetry;    ibuprofen;    paracetamol;   

DOI  :  10.5935/0103-5053.20140005

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

This work presents a simple, fast and low-cost methodology for the simultaneous determination of paracetamol (PC) and ibuprofen (IB) in pharmaceutical formulations by differential pulse voltammetry using a boron-doped diamond (BDD) electrode. A well-defined oxidation peak was observed using the BDD electrode for each analyte (0.85 V for PC and 1.72 V for IB (vs. Ag/AgCl)) in 0.1 mol L-1 H2SO4 solution containing 10% (v/v) of ethanol. Calibration curves for the simultaneous determination of PC and IB showed a linear response for both drugs in a concentration range of 20 to 400 µmol L-1 (r2 = 0.999), with a detection limit of 7.1 µmol L-1 for PC and 3.8 µmol L-1 for IB. The addition-recovery studies in samples were about 100% and the results were validated by chromatographic methods.

【 授权许可】

Unknown