Cobalt(III) complexes with thiosemicarbazones as potential anti-Mycobacterium tuberculosis agents

Journal of the Brazilian Chemical Society

Universidade Federal de Alfenas, Alfenas, Brazil¹  Miyata, Marcelo¹  Maia, Pedro Ivo da S.¹  Oliveira, Carolina G.¹  Universidade Federal do Triângulo Mineiro, Uberaba, Brazil¹  Universidade de São Paulo, São Carlos, Brazil¹  Almeida, Eduardo Tonon de¹  Deflon, Victor M.¹  Universidade Estadual Paulista, Araraquara, Brazil¹  Leite, Clarice Q. F.¹  Pavan, Fernando R.¹ 

关键词: cobalt(III);    thiosemicarbazones;    anti-mycobacterium tuberculosis activity;   

DOI  :  10.5935/0103-5053.20140149

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

CoIII complexes derived from 2-acetylpyridine N(4)-R thiosemicarbazone (Hatc-R, R = alkyl, aryl) have been characterized by elemental analysis, FTIR, UV-Visible and 1H NMR spectroscopies, cyclic voltammetry (CV), conductimetry measurements and single crystal X-ray diffractometry. The results obtained are consistent with the oxidation of the CoII center to CoIII upon coordination of the monoanionic N,N,S-tridentate thiosemicarbazone ligands, resulting in octahedral ionic complexes of the type [Co(atc-R)2]Cl. Electrochemistry studies show two reversible processes referring to the redox couples CoIII/CoII and CoII/CoI which can be modified by the inductive effects of the substituents groups at the N4 position of the ligands. Two CoIII complexes showed satisfactory activity with minimal inhibitory concentration value under 10 µmol L - 1 and one presented quite low cytotoxicity against VERO and J774A.1 cells (IC50), resulting in high selectivity index (SI > 10).

【 授权许可】

Unknown