Inhibitory and enzyme-kinetic Investigation of chelerythrine and lupeol Isolated from Zanthoxylum rhoifolium against krait snake venom acetylcholinesterase

Journal of the Brazilian Chemical Society

Ahmad, Mustaq¹  Zanon, Graciane¹  Ilha, Vinicius¹  University of Science and Technology, Bannu, Pakistan¹  F. Morel, Ademir¹  Dalcol, Ionara I.¹  Weber, Andréia D.¹  Tavares, Luciana de C.¹  Universidade Federal de Santa Maria, Santa Maria, Brazil¹ 

关键词: Zanthoxylum rhoifolium;    chelerythrine;    lupeol;    inhibition of AChE;    venom of the Bungarus sindanus;   

DOI  :  10.5935/0103-5053.20130274

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The in vitro activity of chelerythrine and lupeol, two metabolites isolated from Zanthoxylum rhoifolium were studied against the venom of the snake Bungarus sindanus (Elapidae). The venom, which is highly toxic to humans, consists mainly by the enzyme acetylcholinesterase (AChE). Both compounds showed activity against the venom, and the alkaloid chelerythrine presented higher activity than did triterpene lupeol.

【 授权许可】

Unknown