Microwave-assisted convenient syntheses of 2-indolizine derivatives from Morita-Baylis-Hillman adducts: new in silico potential ion channel modulators

Journal of the Brazilian Chemical Society

Cunha, Saraghina M. D.¹  Vasconcellos, Mário L. A. A.¹  Oliveira, Ramon G. de¹  Universidade Federal da Paraíba, João Pessoa, Brazil¹ 

关键词: Morita-Baylis-Hillman adducts;    2-indolizine derivatives;    microwave;    potential ion channel modulators;    Molinspiration Cheminformatics program;   

DOI  :  10.5935/0103-5053.20130056

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

In this work, a microwave-assisted synthesis study by microwave irradiation to produce indolizine-2-carbonitrile and indolizine-2-carboxylate in good to high yields (70 and 81%, respectively) in one step from Morita-Baylis-Hillman adducts (MBHA) is presented. These compounds were subsequently transformed to high yields (94 to 100%, respectively) in three 2-indolizine derivatives. The five synthesized compounds were designed in silico aiming to present potential selective activities as ion channel modulators. These activities were suggested by the score values using Molinspiration Cheminformatics program.

【 授权许可】

Unknown