Electrochemical homogenous catalysis of the isoflurane reduction in presence of iron(III) tetraphenylporphyrin chloride

Journal of the Brazilian Chemical Society

Sadeghi, Mehdi¹  Imam Hossein University, Tehran, Iran¹  Najafi, Mostafa¹ 

关键词: isoflurane;    anesthetic;    electrocatalytic reduction;    iron porphyrin;   

DOI  :  10.5935/0103-5053.20130215

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The electrochemical reduction of the inhalational anesthetic agent isoflurane was studied at glassy carbon electrode in presence of iron(III) tetraphenylporphyrin chloride (Fe(TPP)Cl) in dimethyl sulfoxide (DMSO) solution. The ability of Fe(TPP)Cl as potential homogenous catalyst for the reduction of isoflurane was tested by cyclic voltammetry and chronomperometry. It showed excellent electrocatalytic ability for the reduction of isoflurane with overpotential of about 1150 mV more positive than the potential for observed reduction of isoflurane in DMSO solution. A linear range between 3.0 × 10-5 and 2.1 × 10-4 mol L-1 for the determination of isoflurane in DMSO solution containing 0.04 mmol L-1 Fe(TPP)Cl was obtained from cyclic voltammetry measurements. The limit of detection was estimated at 1.8 × 10-5 mol L-1. A possible catalytic mechanism is proposed.

【 授权许可】

Unknown