Biological and structure-activity evaluation of chalcone derivatives against bacteria and fungi

Journal of the Brazilian Chemical Society

Universidade Estadual de Goiás, Anápolis, Brazil¹  Camargo, Ademir J.¹  Castro, Miriam. R. C. de¹  Lariucci, Carlito¹  Universidade de Brasília, Brasília, Brazil¹  Napolitano, Hamilton B.¹  Andrade, Carlos Kleber Z.¹  Universidade Federal de Goiás, Goiânia, Brazil¹  Silva, Wender A.¹  Vencato, Ivo¹ 

关键词: chalcones;    biological activities;    X-ray structures;    theoretical calculations;   

DOI  :  10.1590/S0103-50532013000100018

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The present work describes the antibacterial and antifungal activities of several chalcones obtained by a straight Claisen-Schmidt aldol condensation determined by the minimal inhibitory concentration against different microorganisms (Gram-positive and Gram-negative bacteria and fungi). Solid state crystal structures of seven chalcones were determined by X-ray diffraction (XRD) analysis. Chemometric studies were carried out in order to identify a potential structure-activity relationship.

【 授权许可】

Unknown