A new approach for the synthesis of 3-substituted cytotoxic nor-β-lapachones

Journal of the Brazilian Chemical Society

Moraes, Manoel O. de¹  Cardoso, Mariana F. C.¹  Santos, Wilson C.¹  Rocha, David R.¹  Silva, Illana M. C. B. da¹  Araújo, Ana Jérsia¹  Lotufo, Letícia V. C.¹  Silva, Fernando de C. da¹  Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil¹  Universidade Federal do Ceará, Fortaleza, Brazil¹  Santos Júnior, Helvécio M. dos¹  Universidade Federal Fluminense, Niterói, Brazil¹  Ferreira, Vitor F.¹  Pessoa, Claudia¹ 

关键词: naphthoquinone;    heterocycle;    cytotoxicity;    carbohydrate;   

DOI  :  10.1590/S0103-50532013000100003

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Several studies have demonstrated the cytotoxic potential of nor-β-lapachone derivative against cancer cells. Considering nor-β-lapachone as an important prototype, a set of new 3-substituted nor-β-lapachones was synthesized by a new synthetic route that involves the use of synthetic intermediate generated for coupling with several nucleophiles containing the carbohydrate and 2H-pyrazole substituent moieties. All the compounds were screened against four tumor cell lines. Two of the compounds showed moderate cytotoxicity, while the other compounds strongly inhibit all tested cancer cell lines.

【 授权许可】

Unknown