Journal of the Brazilian Chemical Society | |
Multivariate optimization of analytical methodology and a first attempt to an environmental risk assessment of β-blockers in hospital wastewater | |
Martins, Ayrton F.1  Kümmerer, Klaus1  Leuphana University Lüneburg, Lüneburg, Germany1  Federal University of Santa Maria, Santa Maria, Brazil1  Wilde, Marcelo L.1  | |
关键词: risk assessment; hospital wastewater; β-blockers; response surface methodology; SPE-HPLC-FLD; | |
DOI : | |
学科分类:化学(综合) | |
来源: SciELO | |
【 摘 要 】
This preliminary study evaluated an assessment of the risks arising from environmental exposure to β-blockers from wastewater of an university hospital (University Hospital of Santa Maria (HUSM), Rio Grande do Sul State, Brazil). Propranolol showed the highest risk quotient (0.56). The occurrence of β-blockers was evaluated using an analytical procedure SPE-HPLC-FLD (solid phase extraction-high performance liquid chromatography with fluorescence detection), optimizing the variables sample pH, water pH, and methanol:acetonitrile:formic acid ratio of the elution stage. The average concentrations of atenolol, metoprolol and propranolol for a sampling period of one week were 2.45 ± 1.14, 4.67 ± 1.63 and 0.70 ± 0.88 μg L-1 in the 'Emergence' sewage; 0.95 ± 0.68, 0.70 ± 0.33 and 0.315 ± 0.62 μg L-1 in the 'HUSM general' sewage and 1.26 ± 0.47, 1.27 ± 0.35 and 0.56 ± 0.47 μg L-1 in the 'Receiving waters', the receptor stream of the effluents, respectively. Propranolol showed an MEC/PNEC ratio > 1, and thus requires more attention in terms of toxicity. The occurrence of β-blockers and the associated environmental risks demonstrate the need of a more efficient treatment system for the hospital wastewater.
【 授权许可】
Unknown
【 预 览 】
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