Pterodon pubescens benth: stability study of microencapsulated extract and isolated compounds monitored by antinociceptive assays

Journal of the Brazilian Chemical Society

Spindola, Humberto M.¹  Universidade Estadual de Campinas, Campinas, Brazil¹  Universidade Estadual de Campinas, Piracicaba, Brazil¹  Ruiz, Ana L. T. G.¹  Sousa, Ilza M. O.¹  Carvalho, João E. de¹  Rodrigues, Rodney A. F.¹  Servat, Leila¹  Foglio, Mary A.¹ 

关键词: microcapsules;    stability;    spray-drying;    antinociceptive;    Pterodon pubescens;   

DOI  :  10.1590/S0103-50532012000700008

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Pterodon pubescens Benth. (Pp) seeds, commercially available in Brazil, are used in folk medicine in anti-inflammatory, analgesic, and anti-rheumatic preparations. The present study demonstrated the antinociceptive properties of isomers 6α-hydroxy-7β-acetoxy-vouacapan-17β-oate methyl ester and 6α-acetoxy-7β-hydroxy-vouacapan-17β-oate methyl ester (C1), isolated from (Pp), employing different experimental models. A stability study was performed to investigate the relationship of microencapsulation by spray-drying on the maintenance of antinociceptive action. Therefore, C1 and Pp extract samples were monitored in accelerated stability study, evaluating both microencapsulated and non-microencapsulated samples. It was observed that sample C1 possess antinociceptive activity revealed by writhing and formalin tests; C1 showed significantly anti-allodynic, but not antihyperalgesic effect; the microencapsulation maintained the activity and integrity of both, sample C1 and Pp crude extract; microencapsulation by spray drying is a useful alternative to increase shelf life.

【 授权许可】

Unknown