Cytotoxic sesquiterpene lactones and other constituents of Centaurea omphalotricha

Journal of the Brazilian Chemical Society

Bermejo, Jaime¹  Kolli, El Hadj¹  Université Mentouri, Constantine, Algeria¹  Brouard, Ignacio¹  Estévez, Francisco¹  Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain¹  Benayache, Samir¹  Quintana, José¹  CSIC, La Laguna, Spain¹  Estévez, Sara¹  Benayache, Fadila¹  León, Francisco¹ 

关键词: Centaurea;    Asteraceae;    sesquiterpene lactones;    cytotoxic activity;    HL-60;   

DOI  :  10.1590/S0103-50532012000500026

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Phytochemical research of the aerial parts of Centaurea omphalotricha led to the isolation of three new sesquiterpene lactones, 4'-acetyl cynaropicrin, 4'-acetyl cebellin F and 15-acetyl dehydromelitensin, together with twelve known compounds, seven sesquiterpene lactones, two isoprenoids and three flavonoids. The structures of the new compounds were elucidated by means of extensive 1D and 2D NMR, and MS, and by comparison with reported data in the literature. The effect of sesquiterpene lactones on the viability of the human tumor cell lines HL-60 and U937 was also investigated and 3-acetyl cynaropicrin, and 4'-acetyl cynaropicrin were found to be the most cytotoxic compounds against human leukemia cells with an IC50 values of 2.0 ± 0.9 and 5.1 ± 0.4 µmol L-1, respectively.

【 授权许可】

Unknown