Nanostructure of polystyrene-b-poly(2-hydroxyethyl methacrylate) and derivatives with phosphonic diacid groups

Journal of the Brazilian Chemical Society

Giacomelli, Cristiano¹  Schmidt, Vanessa¹  Centre de Recherches sur les Macromolécules Végétales, France¹  Borsali, Redouane¹  Universidade Federal de Santa Maria¹ 

关键词: block copolymers;    self-assembly;    nanostructures;   

DOI  :  10.1590/S0103-50532012000400021

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Surface engineering for precise positioning of biomolecules is of particular interest for controlled fabrication of biochips. In this study, a novel approach for the preparation of nanodomains with phosphonic diacid groups that were previously shown to reversibly bind to a family of proteins (annexins) in a calcium-dependent manner is described. The strategy makes use of polystyrene-b-poly(2-hydroxyethyl methacrylate) (PS-b-PHEMA) precursors prepared by atom transfer radical polymerization (ATRP) to obtain hexagonally packed PS cylinders (fPS = 0.25-0.27) in a PHEMA matrix. The pendant hydroxyl groups of PHEMA are then partially (ca. 20%) converted into phosphonic diacid groups via sequential reactions involving phosphorylation, silylation and methanolysis. This process produces PS-b-P(HEMA-co-PEMA) derivatives that still retain the hexagonal morphology, but their degree of structural organization is reduced comparatively to the precursors.

【 授权许可】

Unknown