Synthesis and phytotoxicity of 4,5 functionalized tetrahydrofuran-2-ones

Journal of the Brazilian Chemical Society

Universidade Federal de Viçosa, Viçosa, Brazil¹  Galindo, Juan C. G.¹  Universidad de Cádiz, Puerto Real, España¹  Macias, Francisco A.¹  Resende, Gabriela C.¹  Alvarenga, Elson S.¹ 

关键词: γ-lactones;    wheat coleoptiles;    herbicide;    Triticum aestivum;   

DOI  :  10.1590/S0103-50532012001200016

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

B> In this work we report a versatile synthesis of fourteen γ-lactones all structurally related, nine of which are novel compounds, accomplished from the readily available furfural. The phytotoxic activity of the synthesized compounds was evaluated in vitro by the influence on the growth of wheat coleoptiles. The percentages of inhibition were mostly small and not statistically different from control after the third dilution (100 µmol L-1). In general, α,β-unsaturated lactones presented better activities than the saturated ones. The most active compounds presented 51, 68 and 76% of inhibition in 1000 µmol L-1. The results indicate that regardless of saturation, the presence of the γ-lactone moiety is important for the bioactivity, but their presence has no implications with potency.

【 授权许可】

Unknown