Metal-catalyzed asymmetric aldol reactions

Journal of the Brazilian Chemical Society

Ferreira, Marco A. B.¹  Polo, Ellen C.¹  University of Campinas (UNICAMP), Campinas, Brazil¹  Lucca Jr., Emílio C. de¹  Dias, Luiz C.¹ 

关键词: aldol reactions;    asymmetric induction;    chiral ligands;    total synthesis;   

DOI  :  10.1590/S0103-50532012001200003

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

B> The aldol reaction is one of the most powerful and versatile methods for the construction of C-C bonds. Traditionally, this reaction was developed in a stoichiometric version; however, great efforts in the development of chiral catalysts for aldol reactions were performed in recent years. Thus, in this review article, the development of metal-mediated chiral catalysts in Mukaiyama-type aldol reaction, reductive aldol reaction and direct aldol reaction are discussed. Moreover, the application of these catalysts in the total synthesis of complex molecules is discussed.

【 授权许可】

Unknown