Optimization and validation of a method using SPE and LC-APCI-MS/MS for determination of pharmaceuticals in surface and public supply water

Journal of the Brazilian Chemical Society

Tomasini, Débora¹  Universidade Federal do Rio Grande, Rio Grande, Brazil¹  Kleemann, Natiele¹  Primel, Ednei G.¹  Cardoso, Liziane V.¹  Gonçalves, Fabio F.¹  Caldas, Sergiane S.¹  Sampaio, Maicon R. F.¹ 

关键词: method validation;    SPE;    LC-APCI-MS/MS;    emergent contaminants;   

DOI  :  10.1590/S0103-50532011001000016

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

In this work, an analytical method based on solid phase extraction (SPE) and liquid chromatography tandem mass spectrometry (LC-APCI-MS/MS) was developed and validated for the determination and confirmation of five pharmaceuticals in water samples. The limits of detection (LOD) ranged from 0.053 to 0.53 µg L-1 and the limits of quantification (LOQ) from 0.16 to 1.6 µg L-1. Good linearity was obtained with r > 0.99 for all compounds. The recoveries of the compounds ranged from 70 to 120% with relative standard deviations (RSD) below 20% for all. Through multiple reactions monitoring (MRM) two different transitions, precursor ion-product ion, were selected for each pharmaceutical.

【 授权许可】

Unknown