Palladium(II) complexes with thiosemicarbazones: syntheses, characterization and cytotoxicity against breast cancer cells and Anti-Mycobacterium tuberculosis activity

Journal of the Brazilian Chemical Society

Graminha, Angélica¹  Universidade de Brasília, Brasília, Brazil¹  Batista, Alzir A.¹  Salistre-de-Araujo, Heloisa S.¹  Deflon, Victor M.¹  Leite, Clarice Q. F.¹  Lang, Ernesto S.¹  Universidade Federal de São Carlos, São Carlos, Brazil¹  Lemos, Sebastião de S.¹  Ellena, Javier¹  Universidade de São Paulo, São Carlos, Brazil¹  Maia, Pedro I. da S.¹  Back, Davi F.¹  Universidade Estadual Paulista, Araraquara, Brazil¹  Pavan, Fernando R.¹  Universidade Federal de Santa Maria, Santa Maria, Brazil¹ 

关键词: palladium(II) complexes;    thiosemicarbazones;    cytotoxicity;    breast tumor cells;    Mycobacterium tuberculosis;   

DOI  :  10.1590/S0103-50532010000700004

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Three PdII complexes were prepared from N(4)-substituted thiosemicarbazones: [Pd(aptsc)(PPh3)](NO3)•H2O, 1, [Pd(apmtsc)(PPh3)](NO3), 2, and [Pd(apptsc)(PPh3)](NO3)•H2O, 3, where PPh3 = triphenylphosphine; Haptsc = 2-acetylpyridine-thiosemicarbazone; Hapmtsc = 2-acetylpyridine-N(4)-methyl-thiosemicarbazone and Happtsc = 2-acetylpyridine-N(4)-phenyl-thiosemicarbazone. All complexes were characterized by elemental analysis, IR, UV-Vis, 1H and 31P{1H} NMR spectroscopies, and had their crystalline structures determined by X-ray diffractometry from single crystals. The monoanionic thiosemicarbazonate ligands act in a tridentate mode, binding to the metal through the pyridine nitrogen, the azomethine nitrogen and the sulfur atoms. The cytotoxic activity against the breast cancer cell line MDA-MB231 and the anti-Mycobacterium tuberculosis H37Rv ATCC 27294 activity were evaluated for the compounds. All PdII complexes were highly active against the studied cell line, presenting similar values of IC50, around 5 µmol L-1, while the clinically applied antitumor agent cisplatin was inactive. The compounds show remarkable anti-M. tuberculosis activities, presenting MIC values comparable or better than some commercial anti-M tuberculosis drugs.

【 授权许可】

Unknown