Counter-Current chromatography separation of isatin derivatives using the sandmeyer methodology

Journal of the Brazilian Chemical Society

Silva, Bárbara V.¹  Almeida, Márcia R.¹  Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil¹  Leitão, Gilda G.¹  Instituto Oswaldo Cruz, Rio de Janeiro, Brazil¹  Barbosa, Jussara P.¹  Pinto, Angelo C.¹ 

关键词: isatins;    Sandmeyer methodology;    isomers separation;    counter-current chromatography;   

DOI  :  10.1590/S0103-50532010000400025

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A rapid and efficient method, using high-speed counter-current chromatography (HSCCC) technique, was developed for the separation of isomeric isatin derivatives, prepared following the Sandmeyer route. The biphasic solvent system composed of hexane:ethyl acetate:ethanol:water 1:0.5:0.5:1 (v/v/v/v) was used for all separations.

【 授权许可】

Unknown