Differential metabolic and biological profiles of Lychnophora ericoides mart. (Asteraceae) from different localities in the Brazilian "campos rupestres"

Journal of the Brazilian Chemical Society

Moraes, Manoel O. de¹  Gobbo-Neto, Leonardo¹  Universidade de São Paulo, Ribeirão Preto, Brazil¹  Pessoa, Cláudia¹  Colepicolo, Pio¹  Universidade Federal do Ceará, Fortaleza, Brazil¹  Costa-Lotufo, Letícia V.¹  Lopes, Norberto P.¹  Universidade de São Paulo, São Paulo, Brazil¹  Embrapa Recursos Genéticos e Biotecnologia, Brasília, Brazil¹  Guaratini, Thais¹  Vieira, Roberto F.¹ 

关键词: Lychnophora ericoides;    secondary metabolite infra-specific variation;    hyphenated techniques;    cytotoxic activity;    antioxidant activity;   

DOI  :  10.1590/S0103-50532010000400023

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

This paper reports HPLC-DAD-MS/MS and HPLC-ECD characterisation of secondary metabolite profiles of Lychnophora ericoides Mart. leaf extracts from different provenances and their cytotoxic and antioxidant properties. Leaf extracts from populations representing seven different locations were evaluated for antioxidant activity by the DPPH radical scavenging system and activity towards cellular growth in three tumor cell lines. The extracts were electrochemically analysed by HPLC-ECD and their main secondary metabolites were identified by HPLC-DAD-MS and HPLC-DAD-MS/MS. An amplified defensive secondary chemistry, together with maximal cytotoxic and antioxidant bioactivities, were found for plants collected at the interface between two types of forest. These findings furnish additional support for the hypothesis that plants occurring at the interface between two forests ecosystems might be stimulated to amplify their own production and storage of defensive secondary metabolites due to the greater number of environmental influences.

【 授权许可】

Unknown