Antifungal activity of natural and synthetic amides from Piper species

Journal of the Brazilian Chemical Society

Oliveira, Alberto de¹  Marques, Joaquim V.¹  Raggi, Ludmila¹  Instituto de Botânica, São Paulo, Brazil¹  Young, Maria C. M.¹  Kato, Massuo J.¹  Universidade de São Paulo, São Paulo, Brazil¹  Universidade Federal de Uberlândia, Uberlândia, Brazil¹ 

关键词: Piper;    antifungal;    analogs;    amides;   

DOI  :  10.1590/S0103-50532010001000003

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The antifungal leaves extract from Piper scutifolium was submitted to bioactivity-guided chromatographic separation against Cladosporium cladosporioides and C. sphaerospermum yielding piperine, piperlonguminine and corcovadine as the active principles which displayed a detection limit of 1 µg. Structure-activity relationships were investigated with the preparation of twelve analogs having differences in the number of unsaturations, aromatic ring substituents and in the amide moiety. Analogs having a single double-bond and no substituent in the aromatic ring displayed higher activity, while N,N,-diethyl analogs displayed higher dose-dependent activity.

【 授权许可】

Unknown