Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes

Journal of the Brazilian Chemical Society

Jabbari, A.¹  Heli, H.¹  K. N. Toosi University of Technology, Tehran, Iran¹  University of Tehran, Tehran, Iran¹  Moosavi-Movahedi, A. A.¹  Faramarzi, F.¹  Parsaei, A.¹  Sobhan Oncology Co., Tehran, Iran¹  Razi University, Kermanshah, Iran¹ 

关键词: etidronate;    bisphosphonate drug;    copper;    nanoparticle;    electrocatalysis;    modified electrode;   

DOI  :  10.1590/S0103-50532010000100004

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The electrochemical behavior and determination of a bisphosphonate drug, sodium etidronate, on three different copper-based electrodes: polycrystalline copper electrode (CE) and copper microparticles- (m-CPE) and copper nanoparticles (n-CPE)-modified carbon paste electrodes was investigated. In the voltammograms recorded using CE, one anodic peak was appeared while, both m-CPE and n-CPE represented two anodic oxidation peaks. The anodic current density at 610 mV for n-CPE is >5 times higher that of m-CPE. This was related to the nanosize effect of copper nanoparticles. The anodic currents were related to the electrocatalytic oxidation of etidronate via the electrogenerated active species of Cu(III) in an EC' mechanism. The catalytic rate constant for the oxidation process and the diffusion coefficient of etidronate were obtained as 8.9×103 cm3 mol-1 s-1 and 1.55×10-6 cm2 s-1, respectively. A sensitive and time-saving sensing procedure was developed for the analysis of etidronate, and the corresponding analytical parameters were reported. Etidronate was determined with a limit of detection of 10.57 μmol L-1 with a linear range of 200-2538 μmol L-1. Accuracy was also checked by recovery test on spiked samples. The proposed amperometric method was applied to the analysis of commercial pharmaceutical tablets and the results were in good agreement with the declared values.

【 授权许可】

Unknown