Characterization of bergenin in Endopleura uchi bark and its anti-inflammatory activity

Journal of the Brazilian Chemical Society

Da Silva, Saulo L.¹  Instituto Nacional de Pesquisas da Amazônia, Manaus, Brazil¹  Oliveira, Viviane G.¹  Universidade Federal do Amazonas, Manaus, Brazil¹  Nunomura, Rita C. S.¹  Nunomura, Sergio M.¹ 

关键词: COX-1;    COX-2;    PLA2;    quantification;    Humiriaceae;    Endopleura uchi;   

DOI  :  10.1590/S0103-50532009000600009

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Endopleura uchi (Huber) Cuatrec. is an Amazon species traditionally used for the treatment of inflammations and female disorders. Pure bergenin was isolated from the methanolic extract of bark of E. uchi, firstly by using liquid-liquid partition chromatography followed by column chromatography over Sephadex LH-20 and then silica gel 60 flash chromatography. The structure of bergenin was identified on the basis of its NMR spectra. The in vitro anti-inflammatory activity was determined by the measurement of the inhibitory concentration (IC) of bergenin against three

【 授权许可】

Unknown