Simultaneous differential pulse voltammetric determination of L-dopa and carbidopa in pharmaceuticals using a carbon paste electrode modified with lead dioxide immobilized in a polyester resin

Journal of the Brazilian Chemical Society

Melo, Hélio Corrêa de¹  Universidade Federal de São Carlos, São Carlos, Brazil¹  Polito, Wagner Luiz¹  Universidade de São Paulo, São Carlos, Brazil¹  Seleghim, Ana Paula D.¹  Vieira, Iolanda C.¹  Universidade Federal de Ouro Preto, Ouro Preto, Brazil¹  Fatibello-Filho, Orlando¹  Universidade Federal de Santa Catarina, Florianópolis, Brazil¹ 

关键词: L-dopa;    carbidopa;    differential pulse voltammetry (DPV);    carbon paste electrode modified with lead dioxide;   

DOI  :  10.1590/S0103-50532007000400019

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A carbon paste electrode modified with lead dioxide immobilized in a polyester resin has been developed for simultaneous differential pulse voltammetric determination of L-dopa and carbidopa in pharmaceutical formulations. The analytical curves were linear in the concentration ranges from 2.6 ´ 10-4 to 1.2 ´ 10-3 mol L-1 and from 3.2 ´ 10-5 to 1.5 ´ 10-4 mol L-1 for L-dopa and carbidopa, respectively. The detection limits were 2.5 ´ 10-5 mol L-1 and 3.7 ´ 10-6 mol L-1 for L-dopa and carbidopa, respectively and recoveries of L-dopa and carbidopa from two samples ranged from 98.1 to 103% of the added amount. The relative standard deviations were lower than 2.5% for 1.2 ´ 10-4 and 1.2 ´ 10-3 mol L-1 of these catecholamines solutions and the results obtained for L-dopa and carbidopa in pharmaceutical formulations using the proposed voltammetric procedure are in close agreement with the labeled values and/or those obtained using an enzymatic method at the 95% confidence level.

【 授权许可】

Unknown