Synthesis of N-substituted 6-trifluoromethyl-1,3-oxazinanes

Journal of the Brazilian Chemical Society

Squizani, Adriana M. C.¹  Zanatta, Nilo¹  Fantinel, Leonardo¹  Bonacorso, Helio G.¹  Borchhardt, Deise M.¹  Martins, Marcos A. P.¹  Nachtigall, Fabiane M.¹  Universidade Federal de Santa Maria, Santa Maria, Brazil¹ 

关键词: g-amino alcohols;    b-enamino ketones;    1;    3-oxazinanes;    1;    3-oxazinan-2-ones;    1;    3-oxazines;   

DOI  :  10.1590/S0103-50532005000700025

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

This work reports the synthesis of two new series of N-substituted 6-trifluoromethyl-1,3-oxazinanes and N-substituted 6-trifluoromethyl-1,3-oxazinan-2-ones from the cyclization of 4-ylamino-1,1,1-trifluoro-butan-2-ols with formaldehyde and triphosgene, respectively. The 4-ylamino-1,1,1-trifluoro-butan-2-ols were obtained in good yields from the reduction of the parent 4-ylamino-1,1,1-trifluoro-but-3-en-2-ones with hydrogen and 10% Pd/C.

【 授权许可】

Unknown