Some Applications of Electrochemistry in Biomedical Chemistry. Emphasis on the Correlation of Electrochemical and Bioactive Properties

Journal of the Brazilian Chemical Society

Goulart, Marília O. F.¹  Universidade Federal de Pernambuco, Recife, Brazil¹  Ferraz, Patrícia A. de L.¹  Abreu, Fabiane C. de¹  Universidade Federal de Alagoas, Maceió, Brazil¹ 

关键词: oxidative stress;    bioreductive alkylation;    tropical diseases;    quinones;    nitroaromatics;    N-oxides;    electron transfer    1. Introduction;   

DOI  :  10.1590/S0103-50532002000100004

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

This review does not intend to cover exhaustively the many areas of research involved, but to provide some background regarding the significance of the electrochemical and electrosynthetic techniques in analysis of natural and synthetic products, in their relationship with bioactive properties, mainly antiparasitical and antitumour activities. In addition, it seeks to provide a brief electrochemical overview of the main classes of bioactive compounds possessing adequate electron transfer functionalities. Electrochemical parameters do not give absolute correlation with biological activity data, due to the enormous complexity of the biomedical chemistry. Indeed, in a live host, this kind of relationship is always a complex outcome not usually dominated by a sole parameter. Caution must be always used in interpreting this kind of correlation. Many other important factors must also be considered in the mechanistic aspects of in vivo drug activity, e.g., stereochemistry, diffusion, solubility, metabolism, membrane permeability, etc.1 Other parameters, like bioavailability, partition coefficient and specific enzyme interactions, also play critical roles. Mention will be made of examples where electrochemistry, dealing with different aspects of electron transfer (ET), contributes significantly to biomedical chemistry. Particular emphasis has been placed upon quinones and nitroaromatics, since the majority of studies reported in the literature concern those classes of compounds.Many of the most important physiological processes are based on oxidoreduction chains involving numerous successive enzyme-catalysed processes. There is a set of similarities between electrochemical and biological reactions concerning electron transfer (ET) pathways, which are not duplicated in other chemical systems.2 Electrochemical studies should furnish an enormous amount of evidence regarding the mechanisms of biological electron-transfer processes.2  2. General Comments This topic should begin with an interesting

【 授权许可】

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